Sharma A., Sharma R., Sharma A., Sharma R.
Florida State University, US
Keywords: atherosclerosis, bioimaging, Cu-64 nanoparticle, multimodal imaging
Nanoparticle based hybrid imaging by MRI, PET-CT and Fluorescent reflectance techniques are emerging in imaging carotid artery disease. 64Cu-TNP is detectable by MRI and PET-CT. A trimodality reporter 64Cu-TNP is a derivatization product made of: 1. the chelator DTPA attached with radiotracer 64Cu and iron oxide core in center provides contrast in MRI imaging(T2, T2*, or steady-state free-precession sequences); 2. fluorochrome attached with 64Cu-TNP is used for fluorescence imaging, including fluorescence microscopy, flow cytometry, and fluorescence-mediated tomography; 3. crosslinked aminated polysaccharide coating provides the biocompatibility and determines the blood half-life and provides linker for attachment of tracers and potentially affinity ligands. The novelty of 64-Cu nanoparticle is that it provides structural, molecular and physiological information same time in carotid artery disease. Other possible techniques based 64-Cu nanoparticles are possible multiple contrast magnetic resonance imaging, susceptibility weighted imaging, positron emission tomography, nanoparticle based imaging, computer tomography, fluorescent based imaging, and fluorescent microscopy but not confirmed yet.
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 70 - 72
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topics: Chemical, Physical & Bio-Sensors, Diagnostics & Bioimaging
ISBN: 978-1-4398-3415-2