Nanotech 2010 Vol. 3
Nanotech 2010 Vol. 3
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy

Bio Sensors, Diagnostics & Imaging Chapter 1

Copper 64-Cu nanoparticles in multimodal imaging of carotid artery disease

Authors: R. Sharma, A. Sharma

Affilation: Florida State University, United States

Pages: 70 - 72

Keywords: Cu-64 nanoparticle, atherosclerosis, bioimaging, multimodal imaging

Nanoparticle based hybrid imaging by MRI, PET-CT and Fluorescent reflectance techniques are emerging in imaging carotid artery disease. 64Cu-TNP is detectable by MRI and PET-CT. A trimodality reporter 64Cu-TNP is a derivatization product made of: 1. the chelator DTPA attached with radiotracer 64Cu and iron oxide core in center provides contrast in MRI imaging(T2, T2*, or steady-state free-precession sequences); 2. fluorochrome attached with 64Cu-TNP is used for fluorescence imaging, including fluorescence microscopy, flow cytometry, and fluorescence-mediated tomography; 3. crosslinked aminated polysaccharide coating provides the biocompatibility and determines the blood half-life and provides linker for attachment of tracers and potentially affinity ligands. The novelty of 64-Cu nanoparticle is that it provides structural, molecular and physiological information same time in carotid artery disease. Other possible techniques based 64-Cu nanoparticles are possible multiple contrast magnetic resonance imaging, susceptibility weighted imaging, positron emission tomography, nanoparticle based imaging, computer tomography, fluorescent based imaging, and fluorescent microscopy but not confirmed yet.

Copper 64-Cu nanoparticles in multimodal imaging of carotid artery disease

ISBN: 978-1-4398-3415-2
Pages: 880
Hardcopy: $189.95