Nano Science and Technology Institute
Nanotech 2010 Vol. 3
Nanotech 2010 Vol. 3
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Chapter 1: Bio Sensors, Diagnostics & Imaging

Nanoparticle-coated nanosprings for diagnostic applications using SERS based detection

Authors:V.V.R. Sai
Affilation:University of Idaho, US
Pages:19 - 22
Keywords:SERS, nanosprings, nanoparticles
Abstract:Significant enhancements in the SERS signals may be obtained with elongated arrangement of silver or gold nanoparticles. Silica nanosprings (NS) with high surface to volume ratio are promising candidate to yield such sensor materials. In this study, Au or Ag NP-coated NS were prepared by different physical or chemical deposition approaches. AgNP-coated NS were found to give better responses compared to AuNP-coated NS, with detection capabilities below 1 attomol (10-18) of thiophenol. The use of these SERS-active materials for ultrasensitive DNA detection using a sandwich nucleic acid assay will be demonstrated.
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