Label-free, Fluorescenece Detection of DNA Nanoparticle Scaffolds

	Nanotech 2010 Vol. 3 Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy Chapter 1: Bio Sensors, Diagnostics & Imaging
	Label-free, Fluorescenece Detection of DNA Nanoparticle Scaffolds
Authors:	A.J. Kell, S. Tan, I. Charlebois, M. Boissinot, M. LeClerc, B. Simard
Affilation:	National Research Council, CA
Pages:	1 - 3
Keywords:	DNA, label-free detection, nanoparticle, polymeric transduction
Abstract:	We have developed a nanoparticle-based DNA biosensor that can detect unlabelled ssDNA with good sensitivity (picomolar concentrations). The biosensor makes use of the optical changes of a cationic polymer interacting with ssDNA versus that of hybridized DNA to provide a fluorescence signal only when a specific hybridization event occurs (i.e. only when perfectly complementary DNA is present)
ISBN:	978-1-4398-3415-2
Pages:	880
Hardcopy:	$189.95

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