Nano Science and Technology Institute
Nanotech 2010 Vol. 3
Nanotech 2010 Vol. 3
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
 
Chapter 1: Bio Sensors, Diagnostics & Imaging
 

Label-free, Fluorescenece Detection of DNA Nanoparticle Scaffolds

Authors:A.J. Kell, S. Tan, I. Charlebois, M. Boissinot, M. LeClerc, B. Simard
Affilation:National Research Council, CA
Pages:1 - 3
Keywords:DNA, label-free detection, nanoparticle, polymeric transduction
Abstract:We have developed a nanoparticle-based DNA biosensor that can detect unlabelled ssDNA with good sensitivity (picomolar concentrations). The biosensor makes use of the optical changes of a cationic polymer interacting with ssDNA versus that of hybridized DNA to provide a fluorescence signal only when a specific hybridization event occurs (i.e. only when perfectly complementary DNA is present)
ISBN:978-1-4398-3415-2
Pages:880
Hardcopy:$189.95
 
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