Nanotech 2010 Vol. 3
Nanotech 2010 Vol. 3
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy

Bio Sensors, Diagnostics & Imaging Chapter 1

Nanopore/electrode structures for single molecule biosensing

Authors: T. Albrecht

Affilation: Imperial College London, United Kingdom

Pages: 15 - 18

Keywords: solid-state nanopores, biosensing, DNA analysis, sequencing

Abstract:
In this contibution I will present some of our work on solid-state nanopores, the fabrication of nanopore/electrode structures and how these can be used for single-molecule biosensing applications (DNA, proteins etc.). Specifically, I will introduce a new way of fabricating small metal nanopores with diameters below 20 nm and well-defined pore conductance, based on electrodeposition and ion-current feedback control. This fabrication method is relatively inexpensive and can easily be multiplexed. Moreover, the surface properties of these metal nanopores can either be switched electrically (by applying a potential) or chemically by molecular self-assembly. Proof-of-concept single-DNA translocation experiments have been performed to show the applicability of the technique to fabricating single-biomolecule sensing devices. Finally, I will present some of our other work in this area on multi-electrode/nanopore devices.

Nanopore/electrode structures for single molecule biosensing

ISBN: 978-1-4398-3415-2
Pages: 880
Hardcopy: $189.95