Authors: T. Zhu, F. Marrero, L. Mao
Affilation: The University of Georgia, United States
Pages: 436 - 441
Keywords: separation, ferrofluids, negative magnetophoresis
We present a simple, effective and label-free continuous flow non-magnetic microparticle separation scheme in a microfluidic device under static magnetic fields. The separation process is based on negative magnetophoresis and uses water-based ferrofluids. We exploit the difference in particle sizes to achieve continuous binary separation of fluorescent microparticles. The prototype device demonstrates high throughput separation of 2 µm and 10 µm particles with close to 100% separation efficiency. This new approach opens the door for the development of label-free particle and cellular separation in microfluidic devices with high throughput, efficiency and reliability.