Nano Science and Technology Institute
Nanotech 2010 Vol. 1
Nanotech 2010 Vol. 1
Nanotechnology 2010: Advanced Materials, CNTs, Particles, Films and Composites
 
Chapter 4: Nanostructured Coatings, Surfaces & Films
 

Non-Silicone Based Nano Thickness Coating to Improve Protein Compatibility

Authors:R. Yeh, M.T. Ling
Affilation:Baxter Healthcare Corportation, US
Pages:624 - 626
Keywords:silicone-free, protein compatible, nano-coating, lubricious, surface treatment, drug delivery devices
Abstract:Medical devices have relied to a large extent on silicone oil surface treatment. A drawback of silicone oil is that it may induce aggregation of proteins in vivo or in vitro. The conformational change of proteins may lead the immune system to consider the aggregated protein as a foreign object, thus stimulating an immune. The purpose of this study is to demonstrate technical concepts of silicone-free surface coating that could be used to design a protein compatible and lubricious surface for drug delivery devices. A proprietary acrylate derivative coating material was developed and its effectiveness as a silicone oil coating material replacement for a syringe system was demonstrated. The materials, which can be synthesized by plasma polymerization for nano thickness coating, have excellent protein drug compatibility. Medical devices coated with the newly developed materials dramatically reduce the loss of expensive protein drugs because of its low protein absorption (figure 1). In addition, the coating materials show better protein compatibility than silicone oil. The coating minimizes the risk of immunogenicity related to protein-silicone oil interactions. This acrylate derivative coating is stable and provides good lubricity and water vapor barrier.
ISBN:978-1-4398-3401-5
Pages:976
Hardcopy:$189.95
 
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