Nano Science and Technology Institute
Nanotech 2009 Vol. 2
Nanotech 2009 Vol. 2
Nanotechnology 2009: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites
Chapter 6: Nano Bio Materials and Tissues

Effects of Crosslinking Condition on Mechanical and Biological Properties of Biomimetic Fibrous Composite Material for Arterial Medial Equivalent

Authors:K. Madhavan, D. Belchenko, W. Tan
Affilation:University of Colorado at Boulder, US
Pages:329 - 332
Keywords:collagen, genipin, viscoelasticity, biocompatibility, smooth muscle cell
Abstract:This study involves the mechanical and biological characterization of crosslinked collagen-based scaffolds for arterial medial-equivalent. These scaffolds are made from a mixture of collagen, chitosan and elastin and crosslinked with genipin. The method of optimization of mechanical and biological properties involves the variation of concentration of components (collagen & chitosan) and crosslinker (genipin). Varying the concentration improves the biomimetic mechanical properties. Even though smooth muscle cells and endothelial cells exhibit high biocompatibility to genipin-crosslinked scaffolds, varying the genipin concentration affects the cell ingrowth in these scaffolds. By striking a balance between the mechanical and biological properties, we are able to design a suitable material.
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