 | Nanotech 2009 Vol. 2
Nanotechnology 2009: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites
Chapter 1: Cancer Nanotechnology |
Anticancer Iron Oxide Nanoparticles | |
| Authors: | F. Benyettou, Y. Lalatonne, O. Sainte-Catherine, M. Lecouvey, L. Motte |
| Affilation: | Laboratoire CSPBAT FRE 3043 CNRS, FR |
| Pages: | 40 - 43 |
| Keywords: | drug nanoparticle, Magnetic nanoparticle, Bisphosphonate, Cancer drugs, Drug targeting |
| Abstract: | We designed a new therapeutic nanoplatform which could be both imaged in situ with MRI (T2 contrast agent) and/or addressed by magnetic targeting (magnet) or specific molecules (peptides, antibodies …). The biological in-vitro tests performed on breast cancer cell line, MDA-MB 231, showed that free alendronate and Fe2O3@Alendronate have similar antiproliferative activity. In addition, we showed that the particles penetrate in cells by endocytosis uptake. Preliminary results of tests in vivo on nude mice show that Fe2O3@Alendronate has antiproliferative properties on breast cancer tumours. Indeed, under a magnetic field, we observed a significant slowdown of the tumours growth for Fe2O3@Alendronate treated mices whereas the free Alendronate molecules have no effect on the tumour growth. |
| ISBN: | 978-1-4398-1783-4 |
| Pages: | 590 |
| Hardcopy: | $179.95 |
| Order: | Mail/Fax Form |
| Special: | 3 CD Set — 15% off with Free Shipping |
| Up |
© 2013 Nano Science and Technology Institute. All Rights Reserved.
Terms of Use | Privacy Policy | Contact Us | Site Map
Terms of Use | Privacy Policy | Contact Us | Site Map