Nano Science and Technology Institute
Nanotech 2008 Vol. 3
Nanotech 2008 Vol. 3
Nanotechnology 2008: Microsystems, Photonics, Sensors, Fluidics, Modeling, and Simulation - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 3
 
Chapter 6: Computational Nanoscience
 

Quantitative Analysis of HBV Capsid Protein Geometry Based Upon Computational Nanotechnology

Authors:H.C. Soundararajan, M. Sivanandam
Affilation:Sri Venkateswara College of Engineering, IN
Pages:673 - 676
Keywords:hepatitis B, capsid, mutation, structure, stability, nanoscale, energetics, molecular modeling
Abstract:Computational biology is an interdisciplinary field that applies the techniques of computer science, functional mathematics and statistics to address problems inspired by biology. Numerous studies have shown that structure of proteins contribute towards their functionality in a direct or indirect way. The structure of viral capsid proteins are critical for hosting and shielding the genetic material and are also crucial for viral entry. In this work, nano-environmental energetics of mutated Hepatitis B capsid protein (HBc) dimer was studied for determining the stability of the protein. Results provide structural information regarding the important residues contributing to Hepatitis B virion (HBV) synthesis. This work illustrates the salience of computational nanotechnology and paves the way for future pharmaceutical applications aimed at destabilization of the capsid-surface protein interactions.
Quantitative Analysis of HBV Capsid Protein Geometry Based Upon Computational NanotechnologyView PDF of paper
ISBN:978-1-4200-8505-1
Pages:940
Hardcopy:$159.95
 
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