Authors: H. Liang, W.J. Nam, S.J. Fonash
Affilation: The Pennsylvania State University, United States
Pages: 281 - 283
Keywords: nanofluidic flow control, nanofluidics, nano-total analysis systems, miniaturized chemical processing
In this work, we introduce the parallel flow control (PFC) configuration shown in Fig. 1 to address these key interfacing and flow control issues. PFC uses flow in a pressure-driven micro-channel, which interfaces with the “outside world”, to set up the pressure gradient across a nano-channel. Based on the size-scale differences between these micro- and nano-channels which are arranged in parallel, micro to nano-channel flow rate ratios of 10E4:1 and higher are easily attainable with the PFC approach thereby allowing the attainment of a broad range of fine nanofluidic flow control. Long residence time and non-uniform flow rate issues are easily avoided by driving a relative large flow rate through the pressure-driven micro-channel. Direct, real-time flow rate measurements in the nano-channel can be achieved by having an additional serpentine measurement micro-channel in series with the nano-channel.