Authors: E. Casler, S. Chae, V. Kunduru, M. Bothara, E. Yang, S. Ghionea, P. Dhagat, S. Prasad
Affilation: Portland State University, United States
Pages: 347 - 350
Keywords: biomarker, cancer, microbead, immunoassay
The goal of this research is to be able to develop a device that would be able to detect and diagnosis pancreatic cancer at bedside. The key criteria to be addressed are the cost, portability, reliability, and non-invasiveness. Pancreatic cancer antigens are coated onto the surface of ferromagnetic microbeads. On the chip itself is the contact surface which is functionalized with the cancer antibodies. The microbeads are then to be flowed over the contact surface and subsequently immobilized due to the antibody/antigen bonds that are formed. The beads not attached to anitbodies are then washed away and only the immobilized beads from the bonds remain. To perform the detection of the beads, a coil is used underneath the contact surface which uses the principles of Faraday’s laws. A magnetic wave sent across the contact surface will result in a disturbance due to the presence of the ferromagnetic beads remaining which emanates a measurable signal.