Authors: R.P. Meagley
Affilation: ONE Nanotechnologies, LLC, United States
Pages: 581 - 584
Keywords: nanodevice arrays, MALDI, SELDI, biomarker screening
Matrix Assisted Laser Desorption Ionization Mass Spectroscopy (MALDI MS) isa particularly efficient tool for proteomics research and diagnostics withprotein biomarkers. Recent innovations in the application of inorganicmatrices have enabled a reduction in noise and concomitant increases insensitivity. However, these inorganic matrices suggest even powerful newtools may be possible. Presented here are new classes of photonic nanodeviceand device arrays for biomarker screening by laser desorption ionizationmass spectrometry. Integration of abiotic recognition and analysis elementsinto the highly sensitive MALDI technique for biomarker assay and discovery,as well as extension to other chemistries including small molecules,biopolymers and nanomaterials, and the incorporation of these effects intomore complex device design and integration strategies.