Bio & Chem Sensors – TechConnect Briefs

A SERS substrate for detection of E.Coli on Nanostructured Poly(p-xylylene)

Kao P., Malvadkar N.A., Wang H., Allara D.L., Demirel M.C., Penn State University, US

Surface enhanced Raman (SERS) has an advantage of minimal sample preparation, low reagent costs and ease of operation in addition to more rapid and reliable biosensing technique when compared to other methods. Several methods have [...]

Nanomonitors: Electrical Immunoassays towards Clinical Diagnostics

Bothara M., Prasad S., Barrett T., Carruthers J., Portland State University, US

We present here the development and tetsing of a protein biosensor operating on electrical capacitance changes as a measure for idnetifying protein biomarkers that are indicators of vulnerale coronary vascular plaque. The prototype of the [...]

Highly passivated silicon chips with micron aperture for the pA measurements of single ion channels

Varnier A., Plénat T., Ghenim L., Marcel-Kermarrec F., Picollet-d’Hahan N., Agache V., Sauter F., Chatelain F., Fuchs A., CEA-Grenoble, FR

Detection of single channel activities on a high throughput device is of major interest for pharmaceutical industries developing new drugs targeting ion channels. A silicon chip, with 9 silicon membranes having a micron aperture each, [...]

Bioreactor with Integrated Nanosensor for the Recording of Extracellular Potential of Nerve Cells: Response oo Inhibitors Record with Algan/Gan Field – Effect Transistor

Cimalla I., Cimalla V., Gebinoga M., Klett M., Lübbers B., Lebedev V., Tonisch K., Cimalla I., Cimalla V., Ambacher O., Schober A., Institute of Micro- and Nanotechnology, TU Ilmenau, DE

Recently sensors based on the group III nitrides attract growing interest in the scientific comunity. It has been shown that sensors made of this material are suitable for recording action potential of muscle cells or [...]

A Comparative Analysis of Iridium Oxide Nanowires in Electrical Detection of Biochemical Reactions

Venkatraman V.L., Reddy R.K., Zhang F., Hsu V., Ulrich B., Prasad S., Portland State University, US

Pt, Ir, Au and few other precious metals have highly conducive electrical and chemical properties; hence have been widely used in pH sensors and biomolecular sensing applications. The chief objective of this research is to [...]

Attachment and Spreading of Human Embryonal Carcinoma Stem Cells on Nanosurfaces Using Optical Waveguides

Aref A., Horvath R., Ansari F., Ramsden J.J., Cranfield University, UK

Abstract Cell adhesion is an active process, carried out in vivo via receptor ligand-like interactions between cell surface adhesion molecules and the extracellular matrix. Initial cell surface reactions following contact may trigger multiple responses, which [...]

DNA Amplification by PCR using Low cost, Programmable Microwave Heating

Garg P., Hella M., Borca-Tasiuc D.-A., Mohamed H., Rensselaer Poytechnic Institute, US

This work presents a low power microstrip transmission line PCR thermo-cycler based on microwave heating that is designed for low-budget, portable/Point of Care (POC) genetic analysis. Previous efforts on miniaturized PCR chambers focused mainly on [...]

Selective Identification of proteins by laser desorption ionization mass spectrometry on photonic nanodevices coupled to abiotic receptors

Meagley R.P., ONE Nanotechnologies, LLC, US

Matrix Assisted Laser Desorption Ionization Mass Spectroscopy (MALDI MS) is a particularly efficient tool for proteomics research and diagnostics with protein biomarkers. Recent innovations in the application of inorganic matrices have enabled a reduction in [...]

Micro-Retroreflectors in Immunoassays and Biosensors

Kemper S.M., Sherlock T., Knoop J.D., Cacao E., Ruchhoeft P., Atmar R.L., Willson R.C., University of Houston, US

Many current bioanalytical and diagnostic methods rely on labeling the species of interest and specialized detection equipment to monitor the label. Common techniques suffer from signal loss or degradation and require the use of equipment [...]

Capacitance signatures for rapid detection of the polarity of the dielectrophoretic force on single yeast cells

Ferrier G.A., Romanuik S.F., Thomson D.J., Bridges G.E., Freeman M.R., University of Manitoba, CA

Previously, we demonstrated a system that can detect the presence of yeast cells using capacitance measurements from a cavity resonator. The resonator is coupled to a set of electrodes, which are aligned 90 degrees relative [...]

Identification of bacterial susceptibility to antibiotics using gold nanoparticles

Perez J.M., Kaittanis C., Nath S., University of Central Florida, US

Inexpensive and rapid methods for detecting bacterial infections and their corresponding susceptibility to antibiotics are desperately needed. The determination of which antibiotic to use and its administration at dosages that will effectively suppress bacterial growth [...]

Polymer nanocomposite based chemiresistive gas sensors

Meka D.A., George L.A., Prasad S., Portland State University, US

We present here the development of a polymer nanocomposite based gas sensor for detecting trace gas emissions in ambient environment. This project is aimed to build a chemiresistive gas sensor with excellent sensitivity and improved [...]

Anodic aluminum oxide-based capacitive humidity sensor integrated with micro-heater

Kim Y.D., Jung B.B., Lee H.K., Lee K.H., Lee H.K., Lee K.H., Park H.C., Pohang University of Science and Technology, KR

AAO(Anodic Aluminum Oxide) film is fabricated as a sensing material of capacitive humidity sensors. Because AAO films have a lot of nano-size pores, many water vapors can be absorbed. The size of a pore diameter [...]

Fabrication of interdigitated nanogap devices for biomolecular detection

Park H.J., Chi Y.S., Ah C.S., Ha D.H., Choi I.S., Yun W.S., Korea Research Institute of Standards and Science (KRISS), KR

One of the most fascinating fields of nanodevice research is its application to the detection of biologically important entities such as DNAs, peptides, antigens, enzymes, viruses, and cells. Nanoelectronic devices adopted in this study are [...]

Polysilicon Nano-wires Based Nano-device on Silicon Chip: Fabrication and its Application

Mishra N.N., Winterrowd P., Nelson R., Maki G., Maki W.C., Rastogi S.K., Cameron E., Filanoski B., Maki G., Maki W.C., University of Idaho, US

5x5 arrays of six nano-transistor devices were fabricated on p-type silicon/silicon oxide (200nm) wafers with resistivity 1-100 -cm. 50nm of doped polysilicon were deposited and annealed to make nanowires. All nanowires were made with direct [...]

Bacterial Concentration Detection with Dielectrophoresis and Capacitive Measurement

Yoo J-H, Cha M.S., Lee J., Seoul National University, KR

The concentration of Escherichia coli (E.coli) cells in water was detected by depositing them on an array of electrodes using dielectrophoresis (DEP). Electrowetting was used to effectively concentrate the E.coli in a droplet of water [...]

Multi-functional Wearable Device for Heart Health and Possition Assesment

Kaminska B., Simon Fraser University, CA

In this paper we introduce a wearable device combining physiological monitoring and person’s position assessment. An accelerometer is used as a multi-functional sensor for a position and heart mechanical performance measurements, known as mechanocardiography (MCG). [...]

Agent Reactive Modulated Optical Reflector for Hazardous Agent Detection

Kovalev A.E., Bray M.G., Mayer T.S., Werner D.H., Pennsylvania State University, US

We demonstrate a standoff passive sensor working in the near infrared range. The device uses a platform based on dielectric and metallo-dielectric layers. The sensor demonstrated a significant change in the reflection coefficient if exposed [...]

Robust Fingerprint Identification System Using Backpropagation and ART Neural Networks

Ilumoka A.A., Talluri M., Eng M., UNIVERSITY OF HARTFORD, US

This paper describes a robust minutiae-based fingerprint identification method suitable for use in small populations. System employs two serially connected neural networks in which fingerprint feature extraction is carried out by the first network – [...]

Micrwave based microfluidic sensor

Tanbakuchi H., Bynum M., Brennen R., Whitener M., Agilent Technologies, US

SPR ( surface Plasmon Resonance) is an non destructive sensor capable of measuring the changes in refractive index above the gold surface (~300 nm) .The advantage of the SPR is in its capability of looking [...]

Identification of PCR Product by double-strand DNA Denaturation using Label-free Field-effect Transistor

Han J., Chung W., Yoo K., Shim J., Samsung Advanced Institute of Technology, KR

We demonstrate an innovative method of PCR product identification that is based on thermal denaturation of PCR products which are immobilized on microbeads using integrated BioFET. Purification step was finished simply by capturing the biotinylated [...]

Label-free and Real-Time Photonic Band-Gap Silica Nanosensor

Chyan J.Y., Yang S.C., Yeh J.A., National Tsing Hua University, TW

A photonic band-gap nanosensor based on porous silica is proposed in the study. The photonic band-gap silica nanosensor is easy to fabricate and simple to use. Its optical characteristics can be easily modulated by electrochemical [...]

Instantaneous Microbial Detection Demonstrated for Air & Water

Jiang J.P., McGill S., Morris S., BioVigilant Systems, Inc., US

Traditionally, growth based techniques have been the standard in environmental monitoring for evaluating the quality and quantity of microbial content. However, many studies have underscored the inadequacy of these techniques: (1) to provide environmental microbial [...]

Optimization of Phage-Based Magnetoelastic Biosensor Performance

Huang S., Yang H., Johnson M., Wan J., Chen I., Petrenko V.A., Chin B.A., Auburn University, US

A magnetoelastic (ME) platform coated with a bio-molecular recognition element (bacteriophage) for selective and specific recognition of Bacillus anthracis spores is described. ME materials have a mass-sensitive, characteristic, resonant frequency. In response to the binding [...]

Real-time detection of neurotransmitter using enzyme-immobilized CNT network transistors in 11 vessel occlusion rat model

Lee G.J., Lim J.E., Park H.J., Park H.K., Park J.H., Eo Y.H., Kim B.S., Park H.J., Park H.K., Park J.H., Choi S.K., Hong S., Park H.J., Park H.K., Park J.H., Kyung Hee University, KR

The field effect transistor (FET) made of carbon nanotube (CNT) can be used as sensor due to their extreme sensitivity to local chemical environments. Glutamate is the principal excitatory neurotransmitter in the brain, and its [...]

Iridium Oxide Nanowire Monitors for Protein Detection

Venkatraman V.L., Reddy R.K., Zhang F., Hsu V., Ulrich B., Prasad S., Portland State University, US

The overarching research objective is the development of a “point-of-care” immunoassay device based on iridium oxide nanowires for disease state identification to predict human health outcomes. This device is based on electrical detection of proteins [...]

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