 | Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 6: Nano Medicine & Neurology |
Multifunctional Polymeric Nanosystems for EGFR Gene Silencing | |
| Authors: | S. Pai, M. Amiji |
| Affilation: | Northeastern University, US |
| Pages: | 512 - 515 |
| Keywords: | muiltifunctional polymeric nanoparticles, siRNA |
| Abstract: | Multifunctional polymeric nanoparticles with an average size of 200nm could be prepared using the solvent displacement technique. Cetyltriethylammonium bromide (CTAB) surface-modified poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticles encapsulated PTX and siRNA with a loading efficiency > 95%. The multifunctional polymeric nanoparticles could successfully deliver siRNA and chemotherapeutic drug simultaneously to cancer cells to silence EGFR and enhance cell kill respectively |
| ISBN: | 978-1-4200-8504-4 |
| Pages: | 808 |
| Hardcopy: | $159.95 |
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