Nanotech 2008 Vol. 2
Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2

Nano Medicine & Neurology Chapter 6

Multifunctional Polymeric Nanosystems for EGFR Gene Silencing

Authors: S. Pai, M. Amiji

Affilation: Northeastern University, United States

Pages: 512 - 515

Keywords: muiltifunctional polymeric nanoparticles, siRNA

Abstract:
Multifunctional polymeric nanoparticles with an average size of 200nm could be prepared using the solvent displacement technique. Cetyltriethylammonium bromide (CTAB) surface-modified poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticles encapsulated PTX and siRNA with a loading efficiency > 95%. The multifunctional polymeric nanoparticles could successfully deliver siRNA and chemotherapeutic drug simultaneously to cancer cells to silence EGFR and enhance cell kill respectively

Multifunctional Polymeric Nanosystems for EGFR Gene Silencing

ISBN: 978-1-4200-8504-4
Pages: 808
Hardcopy: $159.95