Authors: C. Reinsch, U. Rauchhaus, S. Panzner
Affilation: novosom AG, Germany
Pages: 328 - 331
Keywords: siRNA, delivery, in vivo, liposomes
Oligonucleotides (ONs) such as antisense (ASO) or siRNA have created a need for new technologies that further enable the systemic and targeted delivery of these active principles. Here, we describe amphoteric, fully charge-reversible liposomes as a novel carrier concept that overcomes the limitations in biodistribution of cationic vectors systems while keeping functionality.