Nanotech 2008 Vol. 2
Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2

Drug & Gene Delivery Systems Chapter 4

Amphoteric liposomes are a platform for multi-organ delivery of oligonucleotides

Authors: C. Reinsch, U. Rauchhaus, S. Panzner

Affilation: novosom AG, Germany

Pages: 328 - 331

Keywords: siRNA, delivery, in vivo, liposomes

Abstract:
Oligonucleotides (ONs) such as antisense (ASO) or siRNA have created a need for new technologies that further enable the systemic and targeted delivery of these active principles. Here, we describe amphoteric, fully charge-reversible liposomes as a novel carrier concept that overcomes the limitations in biodistribution of cationic vectors systems while keeping functionality.

Amphoteric liposomes are a platform for multi-organ delivery of oligonucleotides

ISBN: 978-1-4200-8504-4
Pages: 808
Hardcopy: $159.95