Nano Science and Technology Institute
Nanotech 2008 Vol. 2
Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
 
Chapter 4: Drug & Gene Delivery Systems
 

Preparation And Evaluation Of In Vitro Release Of Amphiphilic _-Cyclodextrin Or Pla Nanospheres Containing A Hydrophobic Drug

Authors:S. Lin, M. Lahiani-Skiba, N. Naouli, M. Skiba
Affilation:Université de Rouen, FR
Pages:411 - 414
Keywords:mebendazole, amphiphilic-cyclodextrin, PLA, nanospheres
Abstract:Mebendazole (MBZ) is an antihelmintic which belongs to group of benzimidazols. It is used for many intestinal diseases and for other diseases. But its low absorption, its high dosages caused side effects on gastro-intestinal track, which limits its usage. In the present work, new colloidal drug carriers such as nanospheres are used in order to increase its solubility. As a consequence, the plasmatic concentrations of MBZ would increase, and the MBZ dosage could be reduced. Chemically modified cyclodextrins are amphiphilic, they can form colloidal suspensions where some drugs (water soluble or not) can be inserted
Preparation And Evaluation Of In Vitro Release Of Amphiphilic _-Cyclodextrin Or Pla Nanospheres Containing A Hydrophobic DrugView PDF of paper
ISBN:978-1-4200-8504-4
Pages:808
Hardcopy:$159.95
 
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