Authors: MJ. Juan, B. Olalde, MJ. Jurado, V. Saez-Martinez
Affilation: INASMET-Tecnalia, Spain
Pages: 310 - 313
Keywords: spraying, nanogel, scaffolds, drug eluting devices
Big advances are being achieved in the design of new implantable devices. The implant-induced inflammatory reaction remains a significant challenge in this field. Coated scaffolds capable of releasing bioactive agents for inhibiting totally or partially the inflammatory response of the surrounding tissues, are now being regarded as potential useful systems. Polymeric nanoparticles are known to be able to provide a programmable and sustained local drug delivery. Nanogels are becoming useful smart materials due to their capacity to swell and de-swell in a controlled way in response to challenges in the surrounding environment, which makes them useful systems for sustained drug release [1-3]. In addition, biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed to provide an optimal microenvironment for cell proliferation, migration, and differentiation, and guidance for cellular in-growth from host tissue. These scaffolds in the form of foams can mimic the architecture of tissues and act as useful implantable devices . One of the challenges in this field is to develop new techniques for the uniform coating of nanoparticles onto a three-dimensional scaffold. This study describes preliminary results on a novel coating method using spraying techniques for loading nanometric crosslinked hydrogels on 2D and 3D biodegradable scaffolds. This process is fast and low cost and would facilitate the controlled release of bioactive molecules from surface engineered scaffolds.