Nano Science and Technology Institute
Nanotech 2008 Vol. 2
Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 3: Biomarkers, Nano Particles & Materials

Effect of Medical Device Substrate Material on Nanoparticulate Silver Efficacy

Authors:B.J. Dair, K.M. Kennedy, R.S. Casas
Affilation:FDA, US
Pages:188 - 189
Keywords:nanoparticle, silver, antimicrobial, medical device, polymer
Abstract:Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nano-scale regime increases the surface area and hence the availability of silver ions, thereby enhancing their potential antimicrobial efficacy relative to their bulk counterparts. Nano-particulate silver systems have been used as anti-microbial agents for medical device applications such as bandages, wound dressings, surgical masks, endotracheal tubes, and catheters. However the surface onto which the silver nanoparticles are deposited will impact the availability of Ag+ ions due to the chemistry of the substrate surface and its affinity for silver ions. The effect of substrate material on the efficacy of nanoparticulate silver will be discussed, along with the implications of materials selection in medical device applications.
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