Authors: I.V. Reshetov, V.I. Chissov, S.S. Sukharev, V.Y. Timoshenko, V.Y. Sidletskiy, P.A. Forsh
Affilation: P.A.Hertzen Moscow Research Oncological Institute, Russian Federation
Pages: 161 - 163
Keywords: nanoparticles, biodisribution, nervous tissue
Interaction between the nanoparticles and nervous tissue in the process of the damage healing is the object of study in the present work. Laboratory animal (rat) was put into deep narcosis. The Nervus ischiadicus was intersected and anastomosis performed. The suspension of nanoparticles or the native powder of nanoparticles was brought in the place of anastomosis. Then during 1 minute the place of anastomosis underwent the action of AC field or heat. The electrical resistance of the nerve was measured above and below the anastomosis. Conclusions 1. Nanoparticles are biocompatible with respect to the nervous tissue – when in suspension they do not worsen the results of the nerve damages treatment. 2. Nanoparticles decrease the pathological pulsation from the area of damage. 3. Nanoparticles decrease the spread of changes in the macroscopic electrical parameters of nerve tissue, including changes, caused by damage. These observations form bases for the search for the therapeutic applications of silicon nanoparticles with the treatment of the damaged nerves.