Nano Science and Technology Institute
Nanotech 2008 Vol. 2
Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 1: Cancer Diagnostics, Imaging & Treatment

Upconverting nanoparticles for photodynamic therapy

Authors:D.K. Chatterjee, Y. Zhang
Affilation:National University of Singapore, SG
Pages:69 - 72
Keywords:photodynamic therapy, upconversion, cancer, nanoparticles
Abstract:Photodynamic therapy involves killing of diseased cells by excitation of photosensitizer chemicals with high energy light to produce cytotoxic oxygen species from surrounding dissolved oxygen. However, poor tissue penetration of high energy light and hydrophobic photosensitizers limits effectiveness to superficial pathologies. Fluorescent upconversion phosphor nanoparticles convert low energy radiation to higher energy emissions and can be used as ‘nanotransducers’ to activate photosensitizers in deep tissues. We synthesized monodisperse, 50 nm PEI/NaYF4:Yb3+,Er3+ nanoparticles producing green/red emission upon NIR excitation. These were targeted to folate receptors on human colon cancer cells and imaged with high signal-to-background ratio. It was demonstrated that these particles could be excited after deep intra-muscular injection in rats. Fluorescence emission enabled these particles to be simultaneously as molecular probes. Upon NIR excitation, the particles, modified with ZnPC photosensitizer, released singlet oxygen, and after targeted binding to cancer cells, resulted in significant cell destruction. Potential clinical use of these nanoparticles includes imaging and PDT of cancer in deep tissues.
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