Authors: N.H. Levi-Polyachenko, E. Merkel, B.T. Jones, W.D. Wagner, D.L. Carroll, J.H. Stewart IV
Affilation: Wake Forest University Health Sciences, United States
Pages: 57 - 60
Keywords: carbon nanotubes, drug delivery, hyperthermia
A clinically applied method to enhance drug localization for abdominal malignancies of colorectal cancer involves a two-hour perfusion of hyperthermic (40-42ºC) chemotherapeutic agents; however, all cavity tissues are subjected to enhanced drug delivery due to increased cell membrane permeability. Here we show that multi-walled carbon nanotubes near colorectal cancer cell membranes cause rapid hyperthermic heating within seconds, and in the presence of the drugs oxaliplatin or mitomycin C, increase the amount of internalized drug and the effectiveness of the therapy. Concentration dependent infrared absorption of multi-walled nanotubes grown with variable amounts of ferrocene catalyst resulted in the finding that 0.1mg/ml is the most efficient amount for hyperthermia. The method developed herein has potential to be used as a rapid bench to bedside clinical therapeutic agent during the surgical management of peritoneal dissemination of colorectal cancer by significantly reducing treatment times and increasing the amount of chemotherapeutic agent delivered.