Authors: M.L. Cosnier, F. Martin, D. Ratel, F. Berger, P. Caillat
Affilation: Commissariat à l’énergie atomique, France
Pages: 34 - 37
Keywords: cells, micro-nanotechnology, surface modification
We developed a miniaturized biopsy tool for harvesting molecules of interest in delicate areas such as brain. This tool permits harvesting of intact cells permitting genomic analysis on these cells. The sampling tool is manufactured by microtechnology methods rendering it small enough to not damage surrounding tissues. Microtechnology techniques permit to geometrically structure the surface and adding a functionalization in order to manage a gentle capture of the cells in the location of the sampling. By controlling the chemical surface modification we can manage to sample isolated cells or clusters of cells. Recovered cells are capable of growth in culture directly on the tool. This particularity avoids recovering or transfer damaging the cells.