Nano Science and Technology Institute
Nanotech 2008 Vol. 1
Nanotech 2008 Vol. 1
Nanotechnology 2008: Materials, Fabrication, Particles, and Characterization - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 5: Nanoparticles & Applications

Production of Polymer Nanosuspensions Using MicrofluidizerTM Processor Based Processes

Authors:T. Panagiotou, S.V. Mesite, J.M. Bernard, K.J. Chomistek and R.J. Fisher
Affilation:Microfluidics, US
Pages:688 - 691
Keywords:polymers, nanosuspensions, PLGS, drug delivery, microfluidizer
Abstract:Two techniques are reported here that can create nano-suspensions of many different polymers types with varying particle sizes by controlling the formulation and process variables. Microfluidics Reaction Technology (MRT) was used with the solvent anti/solvent precipitation technique. Particle size distribution can be controlled by varying parameters such as processing pressure, degree of supersaturation and the ratio of solvent and anti-solvent streams. The solvent emulsion evaporation technique was implemented using a Microfluidizer Processor; i.e., dissolving a polymer in a solvent, creating a nanoemulsion with an immiscible continuous phase, then solvent evaporation to produce the nanosuspension. Particle size distributions can be controlled by varying process parameters and/or formulation. Nanosuspensions in the range of 50-500 nm with many different polymers have been created successfully using both techniques. Poly(epsilon-caprolactone) (PCL) and poly(D,L-lactide-co-glycolide) (PLGA) are two polymers that have been extensively used for parenteral drug delivery. A PCL suspension with a mean particle size of 220nm was created using MRT by mixing a 20 mg/ml (PCL/acetone) solvent stream with water at a ratio 1:10 (solvent:anti-solvent). PCL nanosuspensions have also been created by dissolving the PCL in methylene chloride, forming an emulsion in water and then vaporizing the solvent.
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