Nano Science and Technology Institute
Nanotech 2007 Vol. 4
Nanotech 2007 Vol. 4
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 4
 
Chapter 2: Nanoparticles
 

Preparation and characterization of release behavior for hydrophilic drug loaded alginate nanohydrogels

Authors:S-M Lee, H-Y Lee, Y-M Kim, M-K Kim, S-O Sohn and H-D Ghim
Affilation:Kyungpook national university, KR
Pages:250 - 253
Keywords:alginate nanohydrogels, hydrophilic drug, controlled release
Abstract:Recently, there have been considerable interests in developing biodegradable nanoparticles as effective drug delivery devices. Alginate is one of the hydrophilic natural polymers having biodegradability and biocompatibility. It has possibility to apply in the controlled release of drugs, targeting particular organs/tissues, as carrier of DNA in gene therapy, and delivery proteins and peptides through a peroral route of administration. In this work, we proposed reverse emulsification-diffusion method to prepare alginate nanohydrogels containing hydrophilic drug and studied various parameters to influence in preparation of them. Physicochemical characteristics and in vitro release behavior of hydrophilic drug loaded alginate nanohydrogels were also investigated to establish them as a novel carrier for controlled release drug delivery system.
Preparation and characterization of release behavior for hydrophilic drug loaded alginate nanohydrogelsView PDF of paper
ISBN:1-4200-6376-6
Pages:768
Hardcopy:$139.95
 
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