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 | Nanotech 2007 Vol. 2
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 9: Cancer Diagnostics, Imaging & Treatment |
| | Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis | | Authors: | M. Fujita, N.M. Khazenzon, B.S. Lee, E. Holler, K.L. Black and J.Y. Ljubimova | | Affilation: | Cedars-Sinai Medical Center, US | | Pages: | 760 - 762 | | Keywords: | nanoconjugate, angiogenesis, tumor markers, tumor-specific drug delivery | | Abstract: | Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to 4 and 1 chains of a vascular basement membrane protein, laminin-8, suppressed its synthesis in vivo. Treatment of glioma-bearing rats significantly diminished tumor vascularity (p | | ISBN: | 1-4200-6183-6 |
| Pages: | 838 |
| Hardcopy: | $199.99 |
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| Order: | Mail/Fax Form |
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