Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

	Nanotech 2007 Vol. 2 Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2 Chapter 9: Cancer Diagnostics, Imaging & Treatment
	Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis
Authors:	M. Fujita, N.M. Khazenzon, B.S. Lee, E. Holler, K.L. Black and J.Y. Ljubimova
Affilation:	Cedars-Sinai Medical Center, US
Pages:	760 - 762
Keywords:	nanoconjugate, angiogenesis, tumor markers, tumor-specific drug delivery
Abstract:	Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 chains of a vascular basement membrane protein, laminin-8, suppressed its synthesis in vivo. Treatment of glioma-bearing rats significantly diminished tumor vascularity (p
ISBN:	1-4200-6183-6
Pages:	838
Hardcopy:	$139.95

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