Nano Science and Technology Institute
Nanotech 2007 Vol. 2
Nanotech 2007 Vol. 2
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
 
Chapter 6: Biosensors
 

Identifying Nanoscale Molecular Binding Events With SPM/AFM

Authors:W.T. Johnson
Affilation:Agilent Technologies, US
Pages:561 - 562
Keywords:AFM, molecular recognition, TREC
Abstract:PicoTRECTM is a chemical/biological detection accessory for the Agilent SPM/AFM (scanning probe microscopy/atomic force microscopy) that combines molecular scale imaging with nanoscale, molecular recognition mapping. It is being used to map interactions between antibodies/antigens and ligands/receptors. TREC (topography and recognition imaging) combines molecular-scale imaging with the sensitivity of a picoNewton-scale single molecule biosensor. PicoTREC resolves molecular recognition events during lateral scanning by processing the asymmetric reduction of the MAC Mode oscillation amplitude that occurs when a tip-bound ligand and its immobilized target interact. In this way, the locations of binding interactions can quickly and easily be determined from their coordinates on the recognition image, along with comparison to the corresponding topography image.
Identifying Nanoscale Molecular Binding Events With SPM/AFMView PDF of paper
ISBN:1-4200-6183-6
Pages:838
Hardcopy:$139.95
 
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