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 | Nanotech 2007 Vol. 2
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 4: Biomarkers & Nanoparticles |
| | A pbpk model to elucidate processes governing distribution and excretion of polyacrylamide nanoparticles | | Authors: | Y. Wenger, O. Jolliet, R. Schneider and M. Philbert | | Affilation: | University of Michigan, US | | Pages: | 267 - 270 | | Keywords: | nanoparticle, polyacrylamide, pharmacokinetics, tissue distribution, physiologically based pharmacokinetic model | | Abstract: | This paper presents a physiologically based pharmacokinetics model that has been calibrated using experimental measurements of biodistribution and excretion of polyacrylamide nanoparticles in rats. The model is capable of establishing the complete mass balance of nanoparticles, including blood content, excretion, and different locations of accumulation (Organs of the RES, peripheral tissues). It explores the basis for scaling and identify key factors affecting the pharmacokinetics of nanoparticles. | | ISBN: | 1-4200-6183-6 |
| Pages: | 838 |
| Hardcopy: | $199.99 |
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