Nano Science and Technology Institute
Nanotech 2007 Vol. 2
Nanotech 2007 Vol. 2
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
 
Chapter 4: Biomarkers & Nanoparticles
 

A pbpk model to elucidate processes governing distribution and excretion of polyacrylamide nanoparticles

Authors:Y. Wenger, O. Jolliet, R. Schneider and M. Philbert
Affilation:University of Michigan, US
Pages:267 - 270
Keywords:nanoparticle, polyacrylamide, pharmacokinetics, tissue distribution, physiologically based pharmacokinetic model
Abstract:This paper presents a physiologically based pharmacokinetics model that has been calibrated using experimental measurements of biodistribution and excretion of polyacrylamide nanoparticles in rats. The model is capable of establishing the complete mass balance of nanoparticles, including blood content, excretion, and different locations of accumulation (Organs of the RES, peripheral tissues). It explores the basis for scaling and identify key factors affecting the pharmacokinetics of nanoparticles.
A pbpk model to elucidate processes governing distribution and excretion of polyacrylamide nanoparticlesView PDF of paper
ISBN:1-4200-6183-6
Pages:838
Hardcopy:$139.95
 
Order:Mail/Fax Form
Up
© 2014 Nano Science and Technology Institute. All Rights Reserved.
Terms of Use | Privacy Policy | Contact Us | Site Map