Nanotech 2007 Vol. 2
Nanotech 2007 Vol. 2
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2

Biomarkers & Nanoparticles Chapter 4

A pbpk model to elucidate processes governing distribution and excretion of polyacrylamide nanoparticles

Authors: Y. Wenger, O. Jolliet, R. Schneider and M. Philbert

Affilation: University of Michigan, United States

Pages: 267 - 270

Keywords: nanoparticle, polyacrylamide, pharmacokinetics, tissue distribution, physiologically based pharmacokinetic model

Abstract:
This paper presents a physiologically based pharmacokinetics model that has been calibrated using experimental measurements of biodistribution and excretion of polyacrylamide nanoparticles in rats. The model is capable of establishing the complete mass balance of nanoparticles, including blood content, excretion, and different locations of accumulation (Organs of the RES, peripheral tissues). It explores the basis for scaling and identify key factors affecting the pharmacokinetics of nanoparticles.


ISBN: 1-4200-6183-6
Pages: 838
Hardcopy: $139.95

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