Authors: Y. Wenger, O. Jolliet, R. Schneider and M. Philbert
Affilation: University of Michigan, United States
Pages: 267 - 270
Keywords: nanoparticle, polyacrylamide, pharmacokinetics, tissue distribution, physiologically based pharmacokinetic model
This paper presents a physiologically based pharmacokinetics model that has been calibrated using experimental measurements of biodistribution and excretion of polyacrylamide nanoparticles in rats. The model is capable of establishing the complete mass balance of nanoparticles, including blood content, excretion, and different locations of accumulation (Organs of the RES, peripheral tissues). It explores the basis for scaling and identify key factors affecting the pharmacokinetics of nanoparticles.