Nanotech 2007 Vol. 2
Nanotech 2007 Vol. 2
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2

Nano Medicine Chapter 10

Nanomedicine: Engineering of a Tri-Imageable Nanoparticle

Authors: A. Bumb, M.W. Brechbiel, P. Choyke, L. Fugger and P.J. Dobson

Affilation: National Cancer Instiute and University of Oxford, United Kingdom

Pages: 772 - 775

Keywords: USPIO, MR, optical, radio, imaging, nanoparticle

Abstract:
We have created a potential targeted drug delivery platform with three imaging reporters by coupling the magnetic properties of USPIOs with near infrared fluorescence of Cy5.5 and gamma emissions of Indium-111 that is chelated to a targeting antibody. The nanoparticles have been characterized for surface charge by zeta potential measurements, structure by transmission electron microscopy, optical response by fluorescence spectrophotometry, and magnetic properties with a superconducting quantum interference device. To test the generalizability of this technology, the particle was conjugated to different antibodies targeting different diseases. A 12.5 and 20.9 signal-to-noise efficiency was found during in vitro studies for multiple sclerosis-targeting and cancer-targeting particles, respectively. Though there are many diagnostic applications of the current structure, the nanoparticle can also be developed into a drug delivery construct, where its superparamagnetic properties are utilized for hyperthermia and controlled drug release.

Nanomedicine: Engineering of a Tri-Imageable Nanoparticle

ISBN: 1-4200-6183-6
Pages: 838
Hardcopy: $139.95