Authors: V.J. Alarcon, W. Kingery and J. Zhu
Affilation: Mississippi State University, United States
Pages: 593 - 597
Keywords: flow-through reactor, polymerase chain reaction (PCR), thermocycling, microchannel, lab-on-a-chip, multiphysics simulation
Estimations of apparent diffusion coefficients usually consist of curve-fitting the output of one-dimensional models to experimental laboratory-measured data from porous aggregates shaped in different forms. In this research a computational exploration is presented on the alternative use of three-dimensional models for the same purpose. Saturated conditions and absence of retention mechanisms for the solute were assumed. The outputs of the three di-mensional models were averaged and compared to the results generated by the one-dimensional formulations. The comparison showed that there are signifi-cant discrepancies in the concentration values output by the models. Percent differences ranging from 30 to 90% were calculated. Those different estima-tions suggest that different values of the apparent diffusion coefficient may be obtained if the three-dimensional solution of the diffusion equation would be used to match experimental results.