Nanotech 2006 Vol. 2
Nanotech 2006 Vol. 2
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2

Drug Delivery Chapter 5

Nanoconjugates of poly(malic acid) with functional modules for drug delivery

Authors: J.Y. Ljubimova , M. Fujita, B.-S. Lee , N.M. Khazenzon, S. Wachsmann-Hogiu, D.L. Farkas, K.L. Black and E. Holler

Affilation: Cedars-Sinai Medical Center, United States

Pages: 354 - 357

Keywords: antisense oligonucleotides, antibodies, tissue targeting, fluorescence imaging, tumor angiogenesis

Abstract:
Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.

Nanoconjugates of poly(malic acid) with functional modules for drug delivery

ISBN: 0-9767985-7-3
Pages: 893
Hardcopy: $119.95