Nanotech 2006 Vol. 2
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 4: Computational Modeling in Life Sciences
Modeling of Cellular Communication
|Authors:||I. Barjis, W. Samarrai, I. Augustin and J. Barjis|
|Affilation:||New York City College of Technology, US|
|Pages:||301 - 304|
|Keywords:||rule based, modeling, cellular communication|
|Abstract:||This paper introduces application of Rule based to molecular biology. In particular, it illustrates how by means of rule based the process of cellular communication can be modeled, and analyzed, where the model could be used for the research purpose and/ or teaching purposes. |
In order to develop a rule-based model for the process of cellular communication, firstly the paper explains molecular reactions of the processes (G-Protein receptor, G-Proteins and cAMP), because the validity of the developed model depends on how well the real processes are identified and highlighted.
Since the emphasis of this paper is on application of rule based modeling rather than the underlying molecular aspects, the molecular and biological events and reactions are not covered in very depth. Only the most important molecular events of the process of cellular communication, needed as an input data for building a rule based model, are described.
Based on the available biological data a rule based model of the cellular communication process is developed. A rule-based system consists of set of objects, set of facts on the objects declaring their properties, and set of rules, conditions and actions on them.
IF (AND (condition1) (condition2)) THEN (action1) ELSE (action2)
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