Nanotech 2006 Vol. 2
Nanotech 2006 Vol. 2
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2

Bio Sensors and Diagnostics Chapter 3

A Simple and Direct Biomolecule Detection Based on a Microwave Resonator

Authors: Y-H Kim, S-I Yoon, S. Park, H-S Kim, Y-J Kim and H-I Jung

Affilation: Yonsei University, Korea

Pages: 213 - 216

Keywords: microwave resonator, CPW-to-slotline ring resonator, biosensor, simple structure, direct detection

Abstract:
We report a simple and direct biomolecule detection method, sensitivity enhancing technique, and its characterization realized by using a CPW-to-slotline ring resonator whose resonant frequency is 3.4 GHz. When a biomolecule is attached on the resonator, it directly detects a biomolecule through its resonant frequency change without an additional transduction procedure.<br>&nbsp;<br>The microwave biosensor was fabricated and characterized through biotin-streptavidin reaction. The results show that its resonant frequency change was 65 MHz and 10 MHz due to biotin and streptavidin binding to the resonator, respectively.<br>To enhance sensitivity, the resonator was modified by increasing reaction area and utilizing a region where electromagnetic field intensity concentrated. Compared to resonant frequency change of the original resonator, that of the modified resonator showed sensitivity enhancement by 21% (79 MHz) and 80% (18 MHz)when biotin and streptavidin was bound.<br>&nbsp;<br>According to the results of the proposed microwave biosensor, it is expected that the biosensor can simplify biomolecule detection process.

A Simple and Direct Biomolecule Detection Based on a Microwave Resonator

ISBN: 0-9767985-7-3
Pages: 893
Hardcopy: $119.95