Papers:
Dendrimer Nanoparticles for Extending Biosensor Lifetime
Smiths Detection has been developing semi-selective optical biosensors for the direct airborne detection of the four primary classes of biological warfare agent: bacteria, bacterial spores, toxins and viruses. The sensors have good sensitivity and selectivity. [...]
Future of Semiconductor Based Thermal Neutron Detectors
Thermal neutron detectors have seen only incremental improvements over the last decades. In this paper we overview the current technology of choice for thermal neutron detection – 3He tubes, which suffer from, moderate to poor [...]
Detection of Biological Species by Surface Enhanced Raman Scattering
The rationale behind this work is to explore the application of surface-enhanced Raman scattering (SERS) to detect and identify biological species, especially some common pathogens that are involved in food poisoning and water contamination. SERS [...]
Multi-plex biomolecular detection using Bio-nanotransduction
Bio-nanotransduction is a biological detection scheme that is based on biological recognition (Bio) and the production of biological nano-signals which allows the change of recognition event into universal signal molecules (nanotransduction). A single sample can [...]
Integrated Techniques for Transmembrane Protein Sensing
Wilk S.J., Petrossian L., Goryll M., Thornton T.J., Goodnick S.M., Tang J.M., Eisenberg R.S., Arizona State University, US
We present a method for the microfabrication of apertures in a silicon substrate using well-known cleanroom technologies and a novel approach using phase sensitive detection to measure single channels of transmembrane proteins. These proteins are [...]
Using Surface Plasmon Propagation through Nanostructures for Chemical and Biological Sensing
By taking advantage of the properties of the propagation of surface plasmon waves through nanostructures, we developed a new chemical and biological sensor. Compared to traditional Surface Plasmon Resonance (SPR) sensing, our sensor does not [...]
Detection of Small Molecule-Protein Binding with Amorphous Silicon Nanostructures
We present the fabrication and characterization of a nano-scale sensor made of amorphous silicon (a-Si) for electronic detection of small molecule –protein binding. The main component of the detector is a nano-scale a-Si semicircle with [...]
Layer by Layer Fabrication of an Amperometric Nanocomposite Biosensor for Sulfite
This paper will present the results of a layer by layer strategy that we have developed for the fabrication of a polypyrrole nanocomposite amperometric biosensor for sulfite. The use of this strategy to fabricate bilayer [...]
Nanoparticle Labels/ Electrochemical Immunosensor for Detection of Biomarkers
A sensitive electrochemical immunoassay based on nanoparticle labels has been developed for the detection of protein biomarker-Macrophage chemoattractant protein 1.The approach is based on a new biosensing principle of the protein biomarker-induced formation of nanoparticles [...]
Polymerized Crystalline Colloidal Arrays Photonic Cosmetic Contact Lenses
We demonstrated the feasibility of making contact lenses from polymerized crystalline colloidal array material to produce beautiful sparkling colors. This material is mainly a poly[HEMA-(ethyleneglycol) 200 dimethacrylate] hydrogel with a crystalline colloidal array (CCA) embedded [...]
CNT-Array Integrated SoC for Biological Sensor Applications
Seo S.M., Cheon J-H, Lee B-Y, Lee J-H., Lee M., Lee B-Y, Lee J-H., Lee M., Im J., Lee B-Y, Lee J-H., Lee M., Chung I-Y, Hong S., Park Y.J., Min H.S., Seoul National University, KR
8x8 carbon nanotube (CNT) arrays are integrated on top of the CMOS chip. The CNTs are functionalized to detect the target ions, and the I-V characteristics are altered by the bio-chemical reaction. The sensing circuit [...]
Novel Photonic Technique Creates Micrometer Resolution Multi-sensor Arrays and Provides a New Approach to Coupling of Genes, Nucleic Acids, Peptide Hormones and Drugs to Nanoparticle Carriers
Neves-Petersen M.T., Duroux L., Duroux M., Duroux L., Duroux M., Skovsen E., Neves-Petersen M.T., Petersen S.B., Professor, DK
Photonic induced immobilisation is a novel patented technology resulting in spatially oriented and localised covalent coupling of biomolecules onto surfaces. Immobilisation has been achieved for a wide selection of proteins, e.g., human plasminogen, alkaline phosphatase, [...]
Electrochemical ‘Lab-on-a-Chip’ for Toxicity Detection in Water
An electrochemical Nano-Bio-Chip for water toxicity detection is presented. Integrating living cells with electronic devices contributes functional information regarding the effect of toxicants on living organisms. Bacteria, which have been genetically engineered to respond to [...]
Electrophoretically Actuated Nanoscale Optoentropic Transduction Mechanisms
Sullivan B., Dehlinger D., Zlatanovic S., Esener S., Heller M.J., University of California San Diego, US
We have identified a novel oscillatory optoentropic transduction mechanism that may enable modern communications theory to augment DNA and protein target detection within complex biological samples. More specifically, we have shown that electric field driven [...]
A Simple and Direct Biomolecule Detection Based on a Microwave Resonator
Kim H-S, Kim Y.H., Kim Y.J., Yoon S-I, Park S., Kim H-S, Kim Y.H., Kim Y.J., Kim H-S, Kim Y.H., Kim Y.J., Jung H-I, Yonsei University, KR
We report a simple and direct biomolecule detection method, sensitivity enhancing technique, and its characterization realized by using a CPW-to-slotline ring resonator whose resonant frequency is 3.4 GHz. When a biomolecule is attached on the [...]
Biomedical Applications of Carbon Nanotubes and the related Cellular Toxicity
Bellucci S., Balasubramanian C., Bergamaschi A., Bottini M., Magrini A., Mustelin T., INFN-Laboratori Nazionali di Frascati, IT
Carbon nanotubes, a form of carbon that did not exist in our environment before being manufactured possess unique chemical, physical, optical, and magnetic properties, which make them suitable for many uses in industrial products and [...]
A Novel, Low Power Biosensor for Real Time Monitoring of Creatinine and Urea in Peritoneal Dialysis
Novel biosensors, based on immobilized creatininase, creatinase and urease are developed, using ISFETs with weak inversion at pH 6-8 and 37.0oC. The ISFETs with circuitry, demonstrate a linear relationship of urea and creatinine at the [...]
PCR-free DNA-based biosensing with polymeric optical hybridization transduction using micro- and submicron-magnetic bead captured on micro-electromagnetic traps
DNA-based biosensor technologies for rapid, sensitive and affordable identification of genetic material are in constant evolution and show great potential in various fields. The ability for such methods to be used directly at point-of-care settings [...]
Development of Nanoprobes as Glucose Biosensors
In 2005, the American Diabetes Association (ADA) reported that 20.8 million people have diabetes, making it the fifth leading cause of death by disease in the USA. The objective is to focus on the development [...]
Carbon Nanotube-based Labels for Sensitive Nucleic Acids Detection
Lee A.C., Ye J.S., Tan S.N., Poenar D., Sheu F.S., Heng C.K., Lim T.M., National University of Singapore, SG
A novel multiple-labelled conjugate with carbon nanotubes (CNTs) to amplify hybridization signal was developed to improve the nucleic acids assay sensitivity. The carboxylated CNTs were functionalized by horseradish peroxidase (HRP) and single-stranded oligonucleotides via diimide-activated [...]
Fabrication of impedimetric sensors for label-free Point-of-Care immunoassay cardiac marker systems, with microfluidic blood flow delivery, and results telemetry to PDA
Tweedie M., Subramanian R., Craig I., McAdams E.T., McLaughlin J.A.D., University of Ulster at Jordanstown, UK
Our recent work has demonstrated the capability to fabricate nanoscale interdigitated electrode-type patterns in gold, using a Focussed Ion Beam. We have also shown the capability to nanotemplate gold, which will allow direct protein attachment, [...]
Assembly of DNA Rotaxanes for AFM Based DNA Sequencing
Spadola Q., Qamar S., Lin L., Lindsay S.M., Ashcroft B., Zhang P., Lindsay S.M., The Biodesign Institute at Arizona State University, US
The desire to sequence DNA is fueled by the knowledge that the information locked inside of genomes can help fields as varied as molecular medicine, bioarcheology, forensics, and environmental science. The challenge is to establish [...]
Surface modification and characterization of a cyclic olefin copolymer for magnetic bead-based stop-flow microfluidic ELISA
This abstract describes a microfluidic platform for simple, highly effective and parallel Enzyme Linked Immuno-Sorbent Assay (ELISA). The method is based on the use of magnetic micro-beads in order to increase the capture rate of [...]
Carbon Microstructures for Glucose Biosensor
In this work we report on a novel design and fabrication of glucose sensor based on carbon post electrode array. Apart from the fact that carbon has a wide electrochemical stability window, one advantage of [...]
Biosensors Fabricated through Electrostatic Assembly of Enzymes/Polyelectrolyte Hybrid Layers on Carbon Nanotubes
Carbon nanotubes (CNTs) have emerged as a new class of nanomaterials that is receiving considerable interest because of their unique structure and mechanical and electronic properties. One promising application of CNTs involves their use in [...]
Magnetic Devices for Ultra High Throughput Biological Analysis
In this report we present an integrated microfluidic cell for detecting and sorting magnetic beads in solution. The cell has been developed for magnetic biosensing, which comprises both magnetoresistive sensors optimized for the detection of [...]
Direct-Write CMOS-Based Laboratory-On-Chip
Over the recent years, the identification of genes which influence many diseases has been highly demanded and now, molecular diagnosis is most promising technology to offer fast and early detection of diseases to a maximum [...]
A Sensitive Peptide-Nanotube Based Pathogen Assay
A novel peptide nanotube-based multiplexed pathogen assay has been developed that has high sensitivity, detecting as few as 100 pathogens per mL in as little as 0.5mL. Multifunctional nanotubes detect viruses by selectively binding antibody [...]
Biomolecular diagnostics by a magnetic lab-on-a-chip
Compared to the established fluorescent labeling method, the use of magnetic markers in biochip sensors has important advantages with respect to the detection of biomolecules at low concentrations. Additionally, the direct availability of an electronic [...]
Nanoengineered Encapsulation of Organic Microcrystal as Novel Biolabels
Here we report on our latest developments for nanoengineered encapsulation and surface design of micro and submicron crystals for biochemcial assay. Improvement has been made by decreasing the size of the organic crystals to submicrometer [...]
Applications of Dielectrophoretic / electrohydrodynamic electrodes for concentration of biological nanoparticles
Dielectrophoresis (DEP) is a phemomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and ananlysing the change in motion with frequency, [...]
Fast and Easy Detection System of Protein Glycosylation by Using Resonant Energy Transfer between Nanoparticles
We construct the new glycosylation detection system using Resonance Energy Transfer (RET) between gold nanoparticles (AuNPs) and semiconductor quantum dots (QDs). RET can be induced by biomolecular interactions between concanavalin A (conA)-conjugated AuNP (conA-AuNP) as [...]
Ligand-dependent changes in the SPR of magnetic nanoparticles
Currently, there is an increasing interest in using magnetite nanoparticles in biological and medical applications. The interest is driven by a combination of their biocompatibility, chemical stability and magnetic properties. Magnetite nanoparticles with diameter 10 [...]
Remote Manipulation of a Robotic Arm by Using Infrared Sensors
This project consists in adapting a remote operation system for a robotic arm by using infrared sensors to control its movements. A personal com-puter was used to send instructions to the robotic arm, instead of [...]
Design of a Wireless Passive Microsensor for Injection into the Human Brain
The design of a sensor for injection into the human brain to aid sufferers of spinal injuries and neurological dissorders is outlined. It is powered and communicates by induction from an external coil, and incorporates [...]
Preservation of DNA and Protein Biofunctionality for Bio-MEMS & NEMS Fabrication
Microfabrication processes especially in silicon are not compatible with biomolecules. For example, silicon processing is commonly performed at high temperatures and makes use of aggressive chemicals. Under these conditions biological materials are denaturated or decomposed. [...]
Reflex-arc on a chip: An in silico cell culture analogue
To overcome the shortcomings of in vitro and animal models we are developing a microscopic cell culture analogue (microCCA) of the spinal reflex-arc. The present work draws on advances in a wide variety of technical [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 7, 2006
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topics: Chemical, Physical & Bio-Sensors, Diagnostics & Bioimaging
ISBN: 0-9767985-7-3