Nano Science and Technology Institute
Nanotech 2006 Vol. 2
Nanotech 2006 Vol. 2
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 1: Cancer Nanotechnology

Functionalization of Magnetite (Fe3O4) Nanoparticles for Cancer Treatment

Authors:A.P. Herrera, H.L. Rodríguez, M. Torres-Lugo and C. Rinaldi
Affilation:University of Puerto Rico-Mayagüez, US
Pages:75 - 78
Keywords:magnetocytolysis, magnetie, dextran, CaCo-2 cell culture
Abstract:We have studied the synthesis of magnetite (Fe3O4) nanoparticles functionalized with crosslinked dextran for magnetocytolysis application using human colon cancer cells (CaCo-2). Size of the magnetite nanoparticles was determined by SQUID, XRD, and TEM measurements, yielding a value of 7-9 nm. Magnetite/crosslinked dextran nanoparticles were found to be non cytotoxic to CaCo-2 cells in the absence of an AC magnetic field. Application of 1.0 kHz 3.0 kA/m magnetic field resulted in a reduction in cell viability to 40 % after 45 min of application.
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