Authors: B.Ya. Kogan, R.I. Yakubovskaya, A.A. Pankratov, T.N. Andreeva, L.D. Kvacheva, A.A. Titov, V.A. Puchnova, R.A. Feysulova and G.N. Vorozhtsov
Affilation: Organic Intermediates & Dyes Institute, Russian Federation
Pages: 71 - 74
Keywords: tumor, carbon nanoparticles, laser irradiation
Light-absorbing nanoparticles incorporated in a tissue can be heated by short-pulsed laser irradiation up to several thousand Kelvin degrees. Average tissue temperature may be kept normal if the concentration of these particles is low. Antitumor effect of such “microexplosions” of nanoparticles against animal tumors has been studied.<br>Colon carcinoma C-26 (Balb/c mice) and sarcoma S-37 (hybrid F1 mice) were used as experimental tumor models. Aqueous suspension of sulphuretted carbon nanoparticles (average nanoparticle size of about 300 nm) was injeсted intravenously in a dose of 30 mg/kg on the 10th (C-26) or 6th (S-37) day after tumor transplantation. Tumors were irradiated by the Q-switched Nd:YAG laser (1.06 m wave-length, 10 ns pulse duration, 3 J/cm2 pulse energy density, 60 or 120 pulses). Hair on the site of irradiation was removed several days before irradiation.<br>Tumor growth kinetics in treated animals was compared with control. Animal death within 7 days after treatment was the criteria of toxicity of this method.<br>Biologically significant 70% tumor growth inhibition was observed in the groups of treated animals. Death of treated mice was not observed within 2 weeks after treatment.