 | Nanotech 2006 Vol. 2
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 1: Cancer Nanotechnology |
Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectrophoresis | |
| Authors: | L. Duncan, H. Shelmerdine, H.M. Coley and F.H. Labeed |
| Affilation: | University of Surrey, UK |
| Pages: | 45 - 48 |
| Keywords: | ion channel, blocker, conductivity, dielectrophoresis |
| Abstract: | Dielectrophoresis (DEP) is a phemomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and ananlysing the change in motion with frequency, it is possible to determine the electrical properties of single cells in lab-on-a-chip systems. In this paper we use DEP to study the electrical properties of drug-sensitive and drug-resistant cancer cells before and after treatment with channel blocking agents, which give insight into the origin of cytoplasmic differences shown to have a significant bearing on the origin of drug resistance in cancer. |
 | View PDF of paper |
| ISBN: | 0-9767985-7-3 |
| Pages: | 893 |
| Hardcopy: | $119.95 |
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