Nanotech 2006 Vol. 1
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 1: Nanoscale Structures and Devices
Cell Separation and Manipulation by magnetic field in the presence of functionalised magnetic nanowires
|Authors:||A. Prina-Mello, Z. Diao and J.M.D. Coey|
|Affilation:||CRANN Research Laboratory, IE|
|Pages:||62 - 63|
|Keywords:||magnetism, nanowires, cell separation, cell alignment,|
|Abstract:||In this paper we investigate the possibility of using magnetic nanowires in cell separation and manipulation. Ni, Co/Cr and Co/Fe nanowires made by electrochemical deposition in anodic aluminum oxide (AAO) templates. The combination between nanowires and different cells such as MC3T3 mouse fibroblasts, UMR-106 has been shown. There, cell viability with all the three kinds (Ni, Co/Cr and Co/Fe) of nanowires after combination was monitored. Magnetic cell separations were carried out following standardized conditions have achieved 75% purity and 75% yield. |
Moreover, we were also successful in aligning the nanowires with cells in a 0.1 T uniform magnetic field. There, the axial of the magnetic nanowires internalised into cells can be aligned to the field direction with uniform magnetic field.
Therefore, a cell-nanowire interaction and living study will be addressed in the future in order to understand the intrinsic mechanisms responsible for cell internalization and alignment.
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