Nano Science and Technology Institute
Nanotech 2005 Vol. 1
Nanotech 2005 Vol. 1
Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 7: DNA, Protein, Cells and Tissue Arrays

New Ferrocene-Functionalized Cationic Polythiophene For Label-Free Electrochemical DNA Detection

Authors:F. Le Floch, H-A Ho, P. Harding-Lepage, M. Leclerc
Affilation:Université Laval, CA
Pages:374 - 376
Keywords:DNA detection, conjugated polymer, ferrocene, PNA
Abstract:A specific polycationic polythiophene was discovered in order to identify dsDNA from ssDNA. The main properties of this new polymer are its conformational possibilities associated with photophysics modifications. This conjugated polymer is still subject to many studies to improve the reconnaissance capacities of genomic sequences. In the meantime many efforts have been made worldwide to develop and improve electrochemical DNA methods because of the possibility of making small portable devices. In spite of many progress and advances in this field, there is still a challenge to find new approaches in order to improve the cost, sensibility, selectivity and simplicity and to respond to new demands and needs in modern medical diagnostics and biomedical research applications. In attempt to develop a multi parametric biosensor with our polycationic polythiophene, we have synthesized a new cationic polythiophene bearing one ferrocene (Fc) group on each monomeric unit.
New Ferrocene-Functionalized Cationic Polythiophene For Label-Free Electrochemical DNA DetectionView PDF of paper
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