Nano Science and Technology Institute
Nanotech 2005 Vol. 1
Nanotech 2005 Vol. 1
Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
 
Chapter 3: Drug Delivery
 

Formation of Nanoparticles of a Hydrophilic Drug using Supercritical CO2 and Microencapsulation for Sustained Drug Release

Authors:A.J. Thote and R.B. Gupta
Affilation:Auburn University, US
Pages:116 - 119
Keywords:sustained, controlled drug release, dexamethasone phosphate, PLGA, SAS-EM, s/o/o/o
Abstract:The problem of initial burst release, in sustained drug delivery devices was resolved by reducing the active pharmaceutical ingredient particle size by using Supercritical Antisolvent technique with Enhanced Mass-transfer (SAS-EM)., Encapsulation was performed using a nonaqueous s/o/o/o technique giving high encapsulation efficiencies for hydrophilic drugs. Using SAS-EM, dexamethasone phosphate nanoparticles were obtained in the range of 150-200 nano-meter. Upon encapsulation in PLGA, composite microspheres of ~70 micro-meter were obtained with about 90% drug encapsulated. The in-vitro drug release study of these microparticle/nanoparticle composites showed sustained drug release over 700 hours with negligible burst release.
Formation of Nanoparticles of a Hydrophilic Drug using Supercritical CO2 and Microencapsulation for Sustained Drug ReleaseView PDF of paper
ISBN:0-9767985-0-6
Pages:844
Hardcopy:$109.95
 
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