Formation of Nanoparticles of a Hydrophilic Drug using Supercritical CO2 and Microencapsulation for Sustained Drug Release

	Nanotech 2005 Vol. 1 Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1 Chapter 3: Drug Delivery
	Formation of Nanoparticles of a Hydrophilic Drug using Supercritical CO2 and Microencapsulation for Sustained Drug Release
Authors:	A.J. Thote and R.B. Gupta
Affilation:	Auburn University, US
Pages:	116 - 119
Keywords:	sustained, controlled drug release, dexamethasone phosphate, PLGA, SAS-EM, s/o/o/o
Abstract:	The problem of initial burst release, in sustained drug delivery devices was resolved by reducing the active pharmaceutical ingredient particle size by using Supercritical Antisolvent technique with Enhanced Mass-transfer (SAS-EM)., Encapsulation was performed using a nonaqueous s/o/o/o technique giving high encapsulation efficiencies for hydrophilic drugs. Using SAS-EM, dexamethasone phosphate nanoparticles were obtained in the range of 150-200 nano-meter. Upon encapsulation in PLGA, composite microspheres of ~70 micro-meter were obtained with about 90% drug encapsulated. The in-vitro drug release study of these microparticle/nanoparticle composites showed sustained drug release over 700 hours with negligible burst release.
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ISBN:	0-9767985-0-6
Pages:	844
Hardcopy:	$109.95

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