Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRI

	Nanotech 2005 Vol. 1 Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1 Chapter 2: Medical Applications
	Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRI
Authors:	C. Sun, O. Veiseh, N. Kohler, J. Gunn, D. Lee, R. Sze, A. Hallahan and M. Zhang
Affilation:	University of Washington, US
Pages:	74 - 77
Keywords:	magnetic resonance imaging, contrast agent, iron oxide nanoparticles, PEG, folic acid, tumor imaging
Abstract:	Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method of cancer detection and diagnosis. In this study, we examine the vitamin folic acid (FA) as a targeting agent for the delivery of superparamagnetic nanoparticles to specific tumor cells in vitro. Results from this study suggest that the synthesized FA-superparamagnetic nanoparticle conjugates can be used to target specific tumor cells for detection by MRI.
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ISBN:	0-9767985-0-6
Pages:	844
Hardcopy:	$109.95

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