Nano Science and Technology Institute
Nanotech 2005 Vol. 1
Nanotech 2005 Vol. 1
Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
 
Chapter 2: Medical Applications
 

Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRI

Authors:C. Sun, O. Veiseh, N. Kohler, J. Gunn, D. Lee, R. Sze, A. Hallahan and M. Zhang
Affilation:University of Washington, US
Pages:74 - 77
Keywords:magnetic resonance imaging, contrast agent, iron oxide nanoparticles, PEG, folic acid, tumor imaging
Abstract:Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method of cancer detection and diagnosis. In this study, we examine the vitamin folic acid (FA) as a targeting agent for the delivery of superparamagnetic nanoparticles to specific tumor cells in vitro. Results from this study suggest that the synthesized FA-superparamagnetic nanoparticle conjugates can be used to target specific tumor cells for detection by MRI.
Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRIView PDF of paper
ISBN:0-9767985-0-6
Pages:844
Hardcopy:$109.95
 
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