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 | Nanotech 2005 Vol. 1
Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 2: Medical Applications |
| | Apoptosis Characterization by Flouro-deoxy Glucose and Intracellular Sodium Distribution Using MicroPET/MRI in PC3 Induced Prostate Cancer in Mice Tumor | | Authors: | R. Sharma, R.P. Kline and J.K. Katz | | Affilation: | Columbia University, US | | Pages: | 71 - 73 | | Keywords: | prostate tumor, FDG-PET. sodium MRI | | Abstract: | Background: Intracellular sodium (IC) and FDG accumulate in premalignant tumor sites. Hypothesis: High FDG and IC accumulation may characterize tumor stages. Objective: To develop rapid noninvasive hybrid microPET/MRI method to characterize PC3 tumor in mice. Methods: Sodium MRI by Inversion recovery pulse sequence on 4.23 T MRI and FDG Conchord microPET estimate and map both IC sodium and FDG at differentiated premalignant and malignant sites. These were confirmed by histology and DNA fragment analysis. Result: Apoptosis, necrosis, carcinoma, sarcoma, neoplasia were confirmed by immunostaining and MRI/PET imaging showed distinct Na and FDG distribution patterns suitable tool for chemosensitivity assay. Conclusion: IC sodium indicates apoptosis and FDG pattern indicates higher glycolysis in both pre-malignant and malignant tumors by rapid imaging. | | ISBN: | 0-9767985-0-6 |
| Pages: | 844 |
| Hardcopy: | $165.00 |
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