Nano Science and Technology Institute
Nanotech 2005 Vol. 1
Nanotech 2005 Vol. 1
Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 2: Medical Applications

Cellular Response to Nanoparticle Exposure

Authors:G.W. Erdos, D. Moraga, M. Palazuelos and K. Powers
Affilation:University of Florida, US
Pages:78 - 80
Keywords:toxicology,apoptosis,lysosomes,electron microscopy
Abstract:Cells exposed to particles will phagocytose them and shuttle the endosomes to lysosomal compartments. Lysosomal mebranes rupture, possibly due to free radical formation. Proteases are released which inturn compromise the mitochondrial membranes. The mitochondria leak cytochrome-c which begins a process leading to apoptotic cell death.
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