Authors: G.W. Erdos, D. Moraga, M. Palazuelos and K. Powers
Affilation: University of Florida, United States
Pages: 78 - 80
Keywords: toxicology,apoptosis,lysosomes,electron microscopy
Cells exposed to particles will phagocytose them and shuttle the endosomes to lysosomal compartments. Lysosomal mebranes rupture, possibly due to free radical formation. Proteases are released which inturn compromise the mitochondrial membranes. The mitochondria leak cytochrome-c which begins a process leading to apoptotic cell death.