Nano Science and Technology Institute
Nanotech 2004 Vol. 1
Nanotech 2004 Vol. 1
Technical Proceedings of the 2004 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 5: Bio Nano Computational Methods and Applications

Resolved Particle Simulations of Microsphere/Cell-based Bioanalytic Systems

Authors:K. Pant, B.F. Romanowicz and S. Sundaram
Affilation:CFD Research Corporation, US
Pages:184 - 187
Keywords:microsphere, cell, assay, design, resolved particle simulations
Abstract:Microsphere and cell-based assays are emerging as the platform of choice for rapid quantitation of biomolecular interactions in bioagent detection, clinical diagnosis, drug therapy, etc. [1,2] Traditional assay designs have been driven by expensive trial-and-error experimentation. The availability of high-fidelity simulation tools for these complex microsystems can help accelerate the design cycle significantly. However, current models rely on a point particle approximation and are incapable of describing large particle dynamics or biochemical coupling adequately. In a novel development, we have successfully developed computational models for finite-sized cells/bead assay design within a multiphysics biomicrofluidic simulation software suite, CFD-ACE+. The developed models fully integrate large bead dynamics, convective-diffusive analyte transport and biomolecular binding on bead surface. In this paper, we present the modeling framework, along with several validation and demonstration case studies.
Resolved Particle Simulations of Microsphere/Cell-based Bioanalytic SystemsView PDF of paper
Order:Mail/Fax Form
© 2017 Nano Science and Technology Institute. All Rights Reserved.
Terms of Use | Privacy Policy | Contact Us | Site Map