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 | Nanotech 2004 Vol. 1
Technical Proceedings of the 2004 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 5: Bio Nano Computational Methods and Applications |
| | Resolved Particle Simulations of Microsphere/Cell-based Bioanalytic Systems | | Authors: | K. Pant, B.F. Romanowicz and S. Sundaram | | Affilation: | CFD Research Corporation, US | | Pages: | 184 - 187 | | Keywords: | microsphere, cell, assay, design, resolved particle simulations | | Abstract: | Microsphere and cell-based assays are emerging as the platform of choice for rapid quantitation of biomolecular interactions in bioagent detection, clinical diagnosis, drug therapy, etc. [1,2] Traditional assay designs have been driven by expensive trial-and-error experimentation. The availability of high-fidelity simulation tools for these complex microsystems can help accelerate the design cycle significantly. However, current models rely on a point particle approximation and are incapable of describing large particle dynamics or biochemical coupling adequately. In a novel development, we have successfully developed computational models for finite-sized cells/bead assay design within a multiphysics biomicrofluidic simulation software suite, CFD-ACE+. The developed models fully integrate large bead dynamics, convective-diffusive analyte transport and biomolecular binding on bead surface. In this paper, we present the modeling framework, along with several validation and demonstration case studies. | | ISBN: | 0-9728422-7-6 |
| Pages: | 521 |
| Hardcopy: | $150.00 |
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