 | Nanotech 2004 Vol. 1
Technical Proceedings of the 2004 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 5: Bio Nano Computational Methods and Applications |
Resolved Particle Simulations of Microsphere/Cell-based Bioanalytic Systems | |
| Authors: | K. Pant, B.F. Romanowicz and S. Sundaram |
| Affilation: | CFD Research Corporation, US |
| Pages: | 184 - 187 |
| Keywords: | microsphere, cell, assay, design, resolved particle simulations |
| Abstract: | Microsphere and cell-based assays are emerging as the platform of choice for rapid quantitation of biomolecular interactions in bioagent detection, clinical diagnosis, drug therapy, etc. [1,2] Traditional assay designs have been driven by expensive trial-and-error experimentation. The availability of high-fidelity simulation tools for these complex microsystems can help accelerate the design cycle significantly. However, current models rely on a point particle approximation and are incapable of describing large particle dynamics or biochemical coupling adequately. In a novel development, we have successfully developed computational models for finite-sized cells/bead assay design within a multiphysics biomicrofluidic simulation software suite, CFD-ACE+. The developed models fully integrate large bead dynamics, convective-diffusive analyte transport and biomolecular binding on bead surface. In this paper, we present the modeling framework, along with several validation and demonstration case studies. |
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| ISBN: | 0-9728422-7-6 |
| Pages: | 521 |
| Hardcopy: | $79.95 |
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