Self Assembly of Globular Protein Nanoparticles

	Nanotech 2004 Vol. 1 Technical Proceedings of the 2004 NSTI Nanotechnology Conference and Trade Show, Volume 1 Chapter 5: Bio Nano Computational Methods and Applications
	Self Assembly of Globular Protein Nanoparticles
Authors:	A. Shiryayev and J.D. Gunton
Affilation:	Lehigh University, US
Pages:	168 - 171
Keywords:	nanoparticle, protein, crystallization, nucleation
Abstract:	A continuum model of the self-assembly of globular protein nanoparticles proposed by Talanquer and Oxtoby (J. Chem. Phys. 109, 223 (1998)) is investigated numerically, with particular emphasis on the region near the metastable fluid-fluid coexistence curve. The free energy barrier that separates a protein rich metastable fluid phase from its stable crystalline phase is studied for a variety of nucleation pathways in the metastable region. As shown earlier, the nucleation barrier is smallest in the vicinity of the fluid-fluid critical point. An approximate analytic solution is also presented for the shape and properties of the nucleating crystal droplet.
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ISBN:	0-9728422-7-6
Pages:	521
Hardcopy:	$79.95

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