Nano Science and Technology Institute
Nanotech 2004 Vol. 1
Nanotech 2004 Vol. 1
Technical Proceedings of the 2004 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 2: Bio Nano Analysis and Characterization

Detection of DNA Hybridyzation with Impedance Amplifying Labels

Authors:K-S Ma, H. Zhou, A. Fischetti, J. Zoval and M. Madou
Affilation:University of California, Irvine, US
Pages:31 - 34
Keywords:DNA, streptavidin, alkaline phosphatase, electrochemical impedance spectroscopy, impedance
Abstract:Traditionally used nucleic acid analysis detection platforms rely on fluorescent or radioactive labels. Optical techniques require large and expensive equipment such as automated colorimetric and fluorimetric instruments that greatly increase the cost of the whole set-up. Working with radioactive labels is an even less attractive option. Electrical measurements of DNA hybridization are expected to involve less complicated and less expensive instrumentation and feature detection limits similar to the traditional optical methods. The diagnostic technique we introduce here will enable low-cost molecular diagnostics methods to become a reality and broaden the extent of the nucleic acid analysis applications.
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