Nano Science and Technology Institute
Nanotech 2004 Vol. 1
Nanotech 2004 Vol. 1
Technical Proceedings of the 2004 NSTI Nanotechnology Conference and Trade Show, Volume 1
Chapter 1: Bio Nano Systems and Chemistry

Nanosecond Pulsed Electric Fields Trigger Intracellular Signals in Human Lymphocytes

Authors:P.T. Vernier, Y. Sun, L. Marcu, C.M. Craft and M.A. Gundersen
Affilation:University of Southern California, US
Pages:7 - 10
Keywords:nanosecond, megavolt-per-meter, calcium burst, electroperturbation, phosphatidylserine translocation
Abstract:We present evidence for a new technological approach to signaling and triggering of intracellular events in biological cells. Remotely applied nanosecond, megavolt-per-meter, pulsed electric fields perturb the intracellular environment, causing calcium release, phosphatidylserine externalization, and apoptosis. This technology does not require direct electrical contacts to biological material. Ultra-short pulses with durations less than the charging time constant of the plasma membrane generate voltages across structures in the cell interior, enabling intracellular manipulations with stimuli that are remotely generated and controlled. The work reported here suggests possibilities within the reach of state-of-the-art bioelectrical engineering and nanotechnology for utilizing nanopulse-triggered intracellular electroperturbations in remote bio-systems deployed as reporters and effectors, and for other applications such as wound healing.
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