Nano Science and Technology Institute
MSM 99
MSM 99
Technical Proceedings of the 1999 International Conference on Modeling and Simulation of Microsystems
Chapter 2: Computational Initiatives in Biotechnology

Structural Genomics and Automated X-ray Crystal Structure Solution

Authors:T.C. Terwilliger and J. Berendzen
Affilation:LANL, US
Pages:42 - 44
Keywords:protein structure, structural genomics, X-ray crystallography, genomics
Abstract:Rapid advances in genomic sequencing are changing the focus and pace of structural biology, shifting from a reductionist approach to a broad view of all the pieces that come into play in a cell or organism. Here we describe how structural information can be obtained in an efficient fashion suitable for genomic-scale structural analyses and discuss recent developments in automation of crystallographic software that will help allow high-throughput structure determination become a reality.
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