Nano Science and Technology Institute
Nanotech 2002 Vol. 1
Nanotech 2002 Vol. 1
Technical Proceedings of the 2002 International Conference on Modeling and Simulation of Microsystems
 
Chapter 2: Micro and Nano Fluidic Systems
 

Macromolecules in Microdevices: Multiscale simulation of DNA dynamics in model microfluidic geometries

Authors:R.M. Jendrejack, J.J. de Pablo and M.D. Graham
Affilation:University of Wisconsin-Madison, US
Pages:88 - 91
Keywords:DNA, microfluidic, hydrodynamic interactions, Brownian dynamics, polymer solutions
Abstract:Simple arguments predict that the dynamics of a dissolved macromolecule confined to a channel comparable to its equilibrium coil size (~1 um for viral DNA) are quite different from those in free solution, because of the no-slip boundary condition on the fluid motion. Nevertheless, detalied, predictive computations have not been previously performed. We have incorporated a Brownian dynamics model of DNA into a fully self-consistent computational scheme that simultaneoulsy resolves the macromolecular and fluid (i.e. solvent) dynamics of DNA in a microfluidic channel. The key novel feature of this scheme is the numerical computation of the Green's function for the flow problem, enabling a stochastic solution method that incorporates detailed hydrodynamics and respects the fluctuation-dissipation theorem. With this methodology we study a number of important confinement effects, focusing here on the retardation of relaxation of a chain in small channel.
Macromolecules in Microdevices: Multiscale simulation of DNA dynamics in model microfluidic geometriesView PDF of paper
ISBN:0-9708275-7-1
Pages:764
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