Authors: B.R. Ringeisen, D.B. Chrisey, A. Piqué, D. Krizman, M. Brooks and B. Spargo
Affilation: Naval Research Laboratory, United States
Pages: 414 - 417
Keywords: direct write, microfluidic device, pluripotent cells, protein microarray, rapid prototyping
The full potential of modeling and simulations is only realized when it is based on experimental results under varied conditions and systems. A single tool to rapidly prototype electronic and biological circuits would enhance the understanding and application of many systems. We have developed a novel laser-based direct write technique which has sub-10 micron resolution and is capable of rapidly prototyping micron-scale passive electronic devices, patterning active biological materials, and micro-machining conformal, flexible, and planar substrates. This manuscript presents our recent efforts to fabricate a living microfluidic device comprised of patterned and differentially cultured pluripotent cells, and to construct an improved antibody microarray capable of rapid and efficient protein identification (proteomics) from malignant and healthy cells.