Nano Science and Technology Institute
MSM 2000
MSM 2000
Technical Proceedings of the 2000 International Conference on Modeling and Simulation of Microsystems
Chapter 13: Applications: Microfluidics

Computational Studies of Membrane-Based Test Formats

Authors:S. Krishnamoorthy, V.B. Makhijani, M. Lei, M.G. Giridharan and T. Tisone
Affilation:CFD Research Corporation, US
Pages:590 - 593
Keywords:rapid diagnostics, lateral-flow, simulation, membrane, quantitation
Abstract:Membrane-based test formats provide simple, accurate and cost effective diagnoses of acute and chronic conditions in general population health. The sensitivity of the immunoassay is determined by the complex biochemical binding kinetics associated with the analyte and receptor molecules in the system. In most flow-through diagnostic systems, the analyte-receptor binding is influenced by the transport of analyte molecules to the receptor surface, which in turn is governed by the flow of sample in the system. Thus, understanding the flow of sample and transport of analyte molecules in a membrane is a crucial step in designing an optimum assay. In the present work, this is accomplished with the help of computational models (CFD-ACE+ from CFD Research Corporation). Line sensitivity analysis and formation of immobile reagent are discussed in the context of a lateral-flow test strip.
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